Effect of exercise on serum creatine kinase in carriers of Duchenne muscular dystrophy.
نویسندگان
چکیده
In order to evaluate the effect of exercise on serum creatine kinase levels, blood samples were obtained from 17 normal females and 12 Duchenne muscular dystrophy carriers before and 9 hours after moderately strenuous exercise. The results revealed that after exercise serum creatine kinase levels may be better indicators of carrier status than resting levels. The mean serum creatine kinase levels before and after exercise, as well as the mean increases, were found to be significantly greater in Duchenne muscular dystrophy carriers than in normal control subjects.
منابع مشابه
Serum creatine kinase studies in the detection of carriers of Duchenne dystrophy.
A number of methods which might improve the detection of carriers of Duchenne muscular dystrophy, based on the estimation of serum creatine kinase (CK), have been tried in an attempt to improve the 70% detection rate obtained with random samples. One series of experiments involved controlled exercise on a bicycle ergometer, the second series was based on sampling of muscle venous blood after co...
متن کاملStudies of the carrier state in the Duchenne type of muscular dystrophy. I. Effect of exercise on serum creatine kinase activity.
The value of estimating the activities of various serum enzymes, particularly creatine kinase (CK) in confirming the diagnosis of the Duchenne type of progressive muscular dystrophy and in detecting the disease in apparently unaffected younger male sibs of known cases is well established (Chung, Morton, and Peters, 1960; Aebi, Richterich, Stillhart, Colombo, and Rossi, 1961; Pearce, Pennington,...
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From the point of view of genetic counselling carrier detection is most important in X-linked disorders. Okinaka et al. (1959) were the first to employ the serum level of creatine kinase to detect female carriers of X-linked Duchenne muscular dystrophy. Since then many investigators have confirmed the usefulness and reliability of this test. So far results on over 200 carriers have been reporte...
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IT has been known for many years that since Duchenne muscular dystrophy is inherited as an X-linked recessive trait only boys will manifest the disease and girls in affected families will have a 50 per cent chance of being genetic carriers of the condition. Although Duchenne dystrophy is a relatively uncommon condition with possibly about 70 patients in Northern Ireland, the number of potential...
متن کاملCarrier detection in Duchenne muscular dystrophy.
Serum creatine kinase, myoglobin, and percentage lymphocyte capping was determined in ten patients with Duchenne muscular dystrophy, 12 carriers (nine definite and three probable), 16 other female relatives, and eight normal controls. There was no detectable difference in lymphocyte capping ability between any of these clinical groups. Significant myoglobinaemia was present in all the affected ...
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ورودعنوان ژورنال:
- Journal of medical genetics
دوره 19 1 شماره
صفحات -
تاریخ انتشار 1982